Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations
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چکیده
منابع مشابه
Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations.
Glutamate dehydrogenase (GDH) catalyses the reversible oxidative deamination of l-glutamate to 2-oxoglutarate in the mitochondrial matrix. In mammals, this enzyme is highly regulated by allosteric effectors. The major allosteric activator and inhibitor are ADP and GTP, respectively; allosteric activation by leucine may play an important role in amino acid-stimulated insulin secretion. The physi...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2002
ISSN: 0264-6021
DOI: 10.1042/0264-6021:3630081